Stabilizing effect of TMAO on globular PNIPAM states: preferential attraction induces preferential hydration

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Stabilizing effect of TMAO on globular PNIPAM states: preferential attraction induces preferential hydration.

We study the effect of the organic co-solute trimethylamine N-oxide (TMAO) on the volume phase transition of microgel particles made from poly(N-isopropylacrylamide) (PNIPAM) using dynamic light scattering (DLS) and all-atom molecular dynamics (MD) simulations. The DLS measurements reveal a continuous TMAO-induced shrinking process from a coil to a globular state of PNIPAM microgel particles. A...

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ژورنال

عنوان ژورنال: Physical Chemistry Chemical Physics

سال: 2016

ISSN: 1463-9076,1463-9084

DOI: 10.1039/c6cp05991k